Apply to wet hair and scalp, massaging in for 1–2 minutes to allow the peptide complex to work on the scalp. Focus application on the scalp rather than just the lengths. Rinse thoroughly. Use 3–4 times a week, or daily if preferred, since it's low-sulfate and gentle enough for frequent use. Follow with the Conditioner.

Apply after shampooing, focusing mainly on the mid-lengths and ends rather than the scalp. Leave on for 1–2 minutes to let the strengthening ingredients absorb. Rinse thoroughly. Use every time you shampoo.

Apply to damp, towel-dried hair after shampooing, focusing on the mid-lengths and ends. Leave on for 5–10 minutes to allow the repair ingredients to penetrate. Rinse thoroughly. Use 1–2 times a week in place of your regular Conditioner.

Apply to wet hair and scalp, massaging in thoroughly. Let it sit on the scalp for 2–3 minutes before rinsing to give the active ingredients time to work. Rinse well. Use 2–3 times a week for active dandruff, reducing to once a week for maintenance once symptoms improve.

Apply directly to a dry or towel-dried scalp, section by section, for direct skin contact. Massage in gently for 30–60 seconds. Do not rinse out. Use daily, ideally on non-wash days, to maintain scalp support between shampoos.

Apply one vial to a clean, dry scalp, distributing it across the areas of concern. Massage in gently with fingertips for 1–2 minutes until absorbed. Do not rinse out. Use as an intensive course following the recommended schedule on the packaging, rather than as a daily long-term product.

Apply to a clean, dry scalp — not soaking wet — parting hair into sections so the lotion reaches the skin directly. Massage in with fingertips for 1–2 minutes to help absorption and boost circulation. Do not rinse out. Use once daily, ideally at a consistent time, for best results.

EGF-Peptides are bioengineered growth factor peptides that support healthy cell communication inside the hair follicle. Unlike botanical extracts that work more superficially, they operate at a cellular signaling level, helping follicles renew properly, stay in their growth phase longer, and maintain overall vitality. Because follicle health underpins nearly every hair concern, EGF-Peptides are included across the collection at different concentrations depending on each product's role — from lighter support in the Shampoo and Conditioner to the highest concentration in the Vials.

Hair loss ingredients — like Procapil™, Redensyl®, Capixyl™ and AnaGain™ — work at the follicle level, targeting the biological mechanisms behind shedding and supporting new growth. Hair repair ingredients — like Hydrolyzed Keratin, Hydrolyzed Silk, Hydrolyzed Collagen and FiberHance™ — work on the hair fiber itself, rebuilding structure and improving strength, elasticity and shine. Most Premetto Secret products combine both types where relevant, since healthy-looking hair depends on a healthy follicle producing a healthy strand.

While EGF-Peptides and the peptide complex are the core actives driving follicle support, ingredients like Caffeine help stimulate scalp circulation, Niacinamide helps regulate oil production, and Panthenol hydrates and soothes the scalp barrier. These supporting ingredients create a more balanced formula overall — addressing scalp comfort and environment alongside the core hair loss and repair actives, rather than leaving those factors unaddressed.

Each of these peptides works on a different part of the hair growth cycle, which naturally moves through phases: growth (anagen), transition (catagen), and shedding (telogen). Redensyl® works on hair follicle stem cells, helping activate them so new hair growth can begin. Capixyl™ combines peptide technology with Red Clover extract to help strengthen the follicle and reduce the shedding that happens when hair is pushed into its resting phase too early. Procapil™ focuses on the connective tissue around the follicle, helping hair anchor in more securely so it's less likely to fall out prematurely. AnaGain™ is designed to reactivate follicles that have gone dormant, essentially helping "wake up" hair growth in areas that have stalled. Together, they intervene at different points in this cycle rather than relying on a single mechanism.

Peptides like EGF-Peptides work by signaling the follicle to behave in healthier ways, but that signal only translates into visible results if the surrounding scalp tissue is well-supported. Copper Tripeptide-1 helps with tissue repair and reduces oxidative stress around the hair bulb — oxidative stress being one of the underlying factors that can damage follicle cells over time. Amino acids like Arginine and Creatine, along with vitamins like Niacinamide and Folic Acid, support general cell health and energy production, which follicles rely on since hair growth is a metabolically demanding process. In short, the peptides give the instruction, and the supporting ingredients help the scalp actually carry it out.